Recruitment Now Open


We are seeking participants in the Sydney area for a clinical trial investigating ‘microdosing’ for the treatment of moderate depression at Macquarie University.

What is involved?

Participants will undergo comprehensive psychiatric screening, and, if eligible, will take part in a 10-week intervention with 6 weeks of drug treatment (two microdoses each week).

What are the risks?

Risks are minimal – there are no associations with dependence, overdose or long-term harm.
The low doses used in this study are not expected to lead to marked changes in conscious awareness.

Who can participate?

Key Inclusion Criteria:
• Major depressive disorder of moderate severity.
• Aged 18+.
• Fluent in English.
• Must not drive yourself to the trial site. We can organise rideshare transport for you if you are within our catchment area or can reimburse you $100 per visit if you are driven by someone else.

Key Exclusion Criteria:
• No comorbid mental illness of greater severity than MDD.
• No use of antidepressant or antipsychotic medication in past 3 months.
• No moderate to severe suicidal ideation in past 12 months.
• No history of psychosis, bipolar disorder, stroke or epilepsy.
• No 1st degree relative with psychosis.

How do I get involved?

Email or phone (02) 7230 1367 and we will send you a survey to assess whether the trial is a good fit for you.